Curcumin (Turmeric) Supresses Inflammation and Pain
Unlike steriods and NSAIDs, the anti-inflammatory activity of curcumin (turmeric) is not restricted to a single factor. Curcumin may also help underlying causes of inflammation. (2, 8)
Safe COX- and COX-2 Inhibitor
Research shows curcumin acts as a scavenger of nitric oxide and inhibits COX-2, a pro-inflammatory substance. Also a potent scavenger of superoxide, the anti-inflammatory activity and superoxide scavenging property of curcumin are proven correlated. Clinically, curcumin has worked as well as cortisone or phenylbutazone for rheumatoid arthritis, osteoarthritis and post-operative inflammation. (1-5)
Curcumin inhibits pain and inflammation and supports homeostasis by selectively inhibiting the arachidonic acid cascade through both the lipoxygenase and cyclooxygenase (COX) pathways (16, 17)
Curcumin has similar anti-inflammatory action as NSAIDS, but without side effects. Unlike aspirin and other classical COX-inhibitors, curcumin selectively inhibits synthesis of inflammatory prostaglandin thromboxane without affecting prostacyclin synthesis, and curcumin thereby protects against vascular thrombosis. (16-21)
COX-inhibitors and NSAIDS have dangerous side-effects; COX-2 inhibitors are required to include black-box warnings. Curcumin is safe, even at doses up to 8,000 mg per day. (10, 11)
Curcumin also inhibits COXs better than indomethacin, a currently prescribed mixed COX inhibitor. (6, 7)
A double-blind crossover study in patients with "definite" rheumatoid arthritis compared the antirheumatic activity of curcumin (1200 mg/day) with phenylbutazone, a corticosteroids drug (300 mg/day). The curcumin therapy resulted in "significant" improvements over corticosteroids. Curcumin better relieved morning stiffness and joint swelling, and improved walking time. Best of all, curcumin was well-tolerated and produced no side-effects. (2, 8)
Curcumin Supresses Systemic Inflammation Markers
Another published study found curcumin substantially suppresses systemic inflammation markers MMP-3 by 48% to 99%, and MMP-13 by 45% to 97%. Researchers concluded curcumin could be useful for reducing cartilage degradation (resorption by MMPs) in arthritis. (2 ,9)




